Reaktion #49348

Reaktionsgleichung

cumylamine

triethylamine

3-fluorobenzoyl chloride

→

3-fluoro-N-(1-methyl-1-phenylethyl)benzamide

Ausbeute 95.3%

Lösungsmittel

dichloromethane

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe mixture was purified by slurry

Vorschrift

In a similar manner to Step 1 of Example 16, 3-fluorobenzoyl chloride (2.00 g, 12.6 mmol) was dissolved in dichloromethane (40 mL), and the solution was treated with cumylamine (1.99 mL, 13.9 mmol), triethylamine (2.63 mL, 18.9 mmol) and DMAP (154 mg, 1.26 mmol). The mixture was purified by slurry using diisopropylether to obtain 3-fluoro-N-(1-methyl-1-phenylethyl)benzamide (3.09 g, yield 95%).

Quelle