Reaktion #49324
ord-5b21d841058348409c428cedfa6f168d
Reaktionsgleichung
4-chloro-7-[1-(tert-butoxycarbonyl)-5-formylindol-2-yl]isoindolinone
3-amino-1-propanol
sodium triacetoxyborohydride
→
4-chloro-7-[1-(tert-butoxycarbonyl)-5-(3-hydroxypropylaminomethyl)indol-2-yl]isoindolinone
Edukte
Reagenzien
Keine
Lösungsmittel
Reaktionsbedingungen
Detaillierte Bedingungen
See reaction.notes.procedure_details.
Vorschrift
In a similar manner to Step 1 of Example 56, 4-chloro-7-[1-(tert-butoxycarbonyl)-5-formylindol-2-yl]isoindolinone (20.0 mg, 0.0487 mmol) was dissolved in dichloromethane (0.5 mL). The solution was treated with 3-amino-1-propanol (0.015 mL, 0.20 mmol) and sodium triacetoxyborohydride (32 mg, 0.15 mmol) to obtain 4-chloro-7-[1-(tert-butoxycarbonyl)-5-(3-hydroxypropylaminomethyl)indol-2-yl]isoindolinone.