Reaktion #493094

Reaktionsgleichung

2-ethyl-5-fluoro-1H-indole

4-piperidone

sodium hydroxide

→

product

Ausbeute 67.3%

2-ethyl-5-fluoro-3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indole

Ausbeute 67.3%

Lösungsmittel

acetic acid

phosphoric acid

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.ADDITIONis added
2. 2
   Extraktionthe product is extracted with ethyl acetate

Vorschrift

2.83 g 2-ethyl-5-fluoro-1H-indole are suspended in 50 ml acetic acid and heated to 90° C. A suspension of 6.66 g 4-piperidone in 15 ml phosphoric acid 2N is added. The reaction mixture is stirred for 3 hours at 90° C., combined with sodium hydroxide solution and the product is extracted with ethyl acetate. 2.85 g product are obtained as a solid.

Quelle