Reaktion #49280

Reaktionsgleichung

3-amino-4-iodo-6-bromophthalimide

2-(tributylstannyl)furan

→

3-amino-4-(furan-2-yl)-6-bromophthalimide

Ausbeute 52.5%

Lösungsmittel

THF

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigefollowed by purification by preparative thin-layer chromatography (chloroform/acetonitrile=50/1, 40/1)

Vorschrift

In a similar manner to Step 1 of Example 10, 3-amino-4-iodo-6-bromophthalimide (100 mg, 0.273 mmol) was dissolved in THF (5 mL), and the solution was treated with 2-(tributylstannyl)furan (0.129 mL, 0.410 mmol) and bis(triphenylphosphine)dichloropalladium (15 mg, 0.022 mmol), followed by purification by preparative thin-layer chromatography (chloroform/acetonitrile=50/1, 40/1) to obtain 3-amino-4-(furan-2-yl)-6-bromophthalimide (44 mg, yield 52%).

Quelle