Reaktion #491548

Reaktionsgleichung

2-fluoro-4-hydroxybenzoic acid

sulfuric acid

MeOH

→

T31.1

Ausbeute 85.0%

Methyl 2-fluoro-4-hydroxybenzoate

Ausbeute 85.0%

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigethe solvent was removed
2. 2
   workup.ADDITIONthe mixture was diluted with diethyl ether
3. 3
   WaschenThe organic phase was washed carefully two times with saturated
4. 4
   Trocknenaqueous NaHCO3, once with brine, and then dried over anhydrous sodium sulfate
5. 5
   FiltrationAfter filtration
6. 6
   Sonstigethe organic solvent was removed in vacuo

Vorschrift

To a round bottom containing 2-fluoro-4-hydroxybenzoic acid (5.34 g, 34.19 mmol) (commercially available from Matrix Scientific and TCI America) was added a cold solution of MeOH (50 mL) and sulfuric acid (2.0 mL). The mixture was heated to 80° C. and monitored with TLC. After 20.5 hours, the solvent was removed, and the mixture was diluted with diethyl ether. The organic phase was washed carefully two times with saturated. aqueous NaHCO3, once with brine, and then dried over anhydrous sodium sulfate. After filtration, the organic solvent was removed in vacuo to yield T31.1 as a white solid (5.82, 85% yield). 1H NMR (400 MHz, DMSO-d6) δ ppm 10.79 (1H, s), 7.75 (1H, t, J=8.8 Hz), 6.69 (1H, dd, J=8.6, 2.3 Hz), 6.62 (1H, dd, J=13.1, 2.2 Hz), 3.78 (3H, s).

Quelle