Reaktion #49090

Reaktionsgleichung

1-[bis(phenylmethyl)amino]cyclopentanecarbonitrile

phenyllithium

di-n-butylether

sodium borohydride

D2

Racemic {1-[amino(phenyl)methyl]cyclopentyl}dimethylamine

→

title compound

Ausbeute 38.0%

(±)-{1-[Amino(phenyl)methyl]cyclopentyl}bis(phenylmethyl)amine

Ausbeute 38.0%

Lösungsmittel

THF

methanol

Reaktionsbedingungen

Vorschrift

The title compound (2.31 g; 38%) was prepared from 1-[bis(phenylmethyl)amino]cyclopentanecarbonitrile D32 (4.0 g; 13.8 mmol), and phenyllithium in di-n-butylether (8.4 ml of 1.8M solution; 15.2 mmol) in THF (80 ml), followed by reaction with sodium borohydride (1.57 g; 41.4 mmol) in methanol (80 ml) in a similar manner to that described in D2. Mass Spectrum (Electrospray LC/MS), API+: Found 371 (MH+). C26H30N2 requires 370. Ret. time 2.62 min.

Quelle