Reaktion #49082

ord-feda3fe98f2649c7b3125abf4becb93a

Reaktionsgleichung

CN(C)C1(C#N)CCCC1
D1
CN(C)C1(C#N)CCCC1
1-(dimethylamino)cyclopentanecarbonitrile
CNC.Cl
dimethylamine hydrochloride
CCC(C)=O
2-butanone
[C-]#N.[K+]
potassium cyanide
→
CCC(C)(C#N)N(C)C
title compound
Ausbeute 78.0%
CCC(C)(C#N)N(C)C
2-(Dimethylamino)-2-methylbutanenitrile
Ausbeute 78.0%

Edukte

CN(C)C1(C#N)CCCC1
D1
CN(C)C1(C#N)CCCC1
1-(dimethylamino)cyclopentanecarbonitrile
CNC.Cl
dimethylamine hydrochloride
CCC(C)=O
2-butanone
[C-]#N.[K+]
potassium cyanide

Reagenzien

Keine

Lösungsmittel

O
water

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

The title compound (9.95 g, 78%) was prepared from dimethylamine hydrochloride (8.15 g, 0.1 mol), 2-butanone (8.96 ml, 0.1 mol) and potassium cyanide (6.51 g, 0.1 mol) in water (50 ml) in a similar manner to that described in D1. 1H NMR (CDCl3) δ: 1.00 (3H, t, J=7.2 Hz), 1.43 (3H, s), 1.75-1.87 (2H, m), 2.33 (6H, s).

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US07745642B2uspto-grants-2010_06