Reaktion #49080

ord-fdeac761ed134756b5116e11b959d866

Reaktionsgleichung

CC(C)(C#N)N1CCCC1
D4
CC(C)(C#N)N1CCCC1
2-methyl-2-(1-pyrrolidinyl)propanenitrile
C1CCNC1
pyrrolidine
CCC(C)=O
2-butanone
[C-]#N.[K+]
potassium cyanide
→
CCC(C)(C#N)N1CCCC1
title compound
Ausbeute 63.0%
CCC(C)(C#N)N1CCCC1
2-Methyl-2-(1-pyrrolidinyl)butanenitrile
Ausbeute 63.0%

Edukte

CC(C)(C#N)N1CCCC1
D4
CC(C)(C#N)N1CCCC1
2-methyl-2-(1-pyrrolidinyl)propanenitrile
C1CCNC1
pyrrolidine
CCC(C)=O
2-butanone
[C-]#N.[K+]
potassium cyanide

Reagenzien

Keine

Lösungsmittel

O
water

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

The title compound (9.6 g, 63%) was prepared from pyrrolidine (8.35 ml, 0.1 mol), 2-butanone (8.96 g, 0.1 mol) and potassium cyanide (6.51 g, 0.1 mol) in water (50 ml) in a similar manner to that described in D4. 1H NMR (CDCl3) δ: 1.06 (3H, t, J=7.2 Hz), 1.45 (3H, s), 1.66-1.93 (6H, m), 2.70-2.75 (4H, m).

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US07745642B2uspto-grants-2010_06