Reaktion #49066

Reaktionsgleichung

D1

1-(dimethylamino)cyclopentanecarbonitrile

piperidine hydrochloride

acetone

potassium cyanide

→

title compound

Ausbeute 77.0%

2-Methyl-2-(1-piperidinyl)propanenitrile

Ausbeute 77.0%

Lösungsmittel

water

Reaktionsbedingungen

Vorschrift

The title compound (2.33 g, 77%) was prepared from piperidine hydrochloride (2.43 g, 20 mmol), acetone (1.16 g, 20 mmol) and potassium cyanide (1.30 g, 20 mmol) in water (10 ml) in a similar manner to that described in D1. 1H NMR (CDCl3) δ: 1.46 (2H, m), 1.50 (6H, s), 1.63 (4H, m), 2.59 (4H, m).

Quelle