Reaktion #49064

Reaktionsgleichung

pyrrolidine

acetone

potassium cyanide

→

title product

Ausbeute 78.0%

2-Methyl-2-(1-pyrrolidinyl)propanenitrile

Ausbeute 78.0%

Lösungsmittel

water

Reaktionsbedingungen

Aufarbeitung

1. 1
   TemperaturTo a stirred, ice-cooled
2. 2
   Sonstigethe crude reaction mixture
3. 3
   Extraktionwas extracted with diethyl ether (2×250 ml)
4. 4
   Waschenthe combined extracts washed with saturated brine (150 ml)
5. 5
   Trocknendried (MgSO4)
6. 6
   Sonstigeevaporated under reduced pressure

Vorschrift

To a stirred, ice-cooled mixture of pyrrolidine (8.35 ml; 0.1 mol) and acetone (7.34 ml; 0.1 mol) was added a solution of potassium cyanide (6.51 g; 0.1 mol) in water (50 ml) dropwise over 10 min. After stirring at room temperature overnight, the crude reaction mixture was extracted with diethyl ether (2×250 ml) and the combined extracts washed with saturated brine (150 ml), dried (MgSO4), and evaporated under reduced pressure to afford the title product as a pale green liquid (10.7 g; 78%) which was used without further purification. 1H NMR (CDCl3) δ: 1.51 (6H, s), 1.80-1.90 (4H, m), 2.70-2.80 (4H, m).

Quelle