Reaktion #49022

Reaktionsgleichung

3-(1-ethoxy-ethylideneaminooxy)-propanoic acid methyl ester

n-propylamine

→

N-(2-propylcarbamoyl-ethoxy)-acetimidic acid ethyl ester

Ausbeute 86.0%

Lösungsmittel

methanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   EinengenThe reaction mixture was concentrated under reduced pressure
2. 2
   Sonstigethe residue was purified by silica gel column chromatography

Vorschrift

To a known compound, 3-(1-ethoxy-ethylideneaminooxy)-propanoic acid methyl ester (CAS No. 97164-30-2, 300 mg, 1.585 mmol) were added methanol (3 ml) and n-propylamine (1.3 ml), and the mixture was stirred at 55° C. for 15 hours. The reaction mixture was concentrated under reduced pressure, and the residue was purified by silica gel column chromatography to give N-(2-propylcarbamoyl-ethoxy)-acetimidic acid ethyl ester (296 mg, 86% yield).

Quelle