Reaktion #490007

Reaktionsgleichung

1,3-dibromo-2-chloro-5-methylbenzene

NBS

AIBN

→

title compound

Ausbeute 57.9%

1,3-dibromo-5-(bromomethyl)-2-chlorobenzene

Ausbeute 57.9%

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturheated to 80° C. overnight
2. 2
   SonstigeThe solution was evaporated
3. 3
   Sonstigethe residue was purified by silica gel chromatography (0-5% EtOAc/heaxnes)

Vorschrift

To 1,3-dibromo-2-chloro-5-methylbenzene (1000 mg, 3.52 mmol) was added NBS (688 mg, 3.87 mmol) and AIBN (57.7 mg, 0.352 mmol). The mixture was stirred at room temperature for 30 minutes and then heated to 80° C. overnight. The solution was evaporated and the residue was purified by silica gel chromatography (0-5% EtOAc/heaxnes) to provide the title compound (740 mg) as a clear oil.

Quelle