Reaktion #489992

Reaktionsgleichung

8-chloro-4,4-dimethyl-3,4-dihydro-2H-thiochromene-6-carbaldehyde

X-Phos

potassium carbonate

potassium cyclopropyltrifluoroborate

→

desired product

8-cyclopropyl-4,4-dimethyl-3,4-dihydro-2H-thiochromene-6-carbaldehyde

Reaktionsbedingungen

Vorschrift

Using essentially the same procedure as Example 5-22, Step 4, Pd(OAc)2 (5.18 mg, 0.02 mmol), X-Phos (22.0 mg, 0.05 mmol), potassium carbonate (319 mg, 2.30 mmol), potassium cyclopropyltrifluoroborate (125 mg, 0.84 mmol), and 8-chloro-4,4-dimethyl-3,4-dihydro-2H-thiochromene-6-carbaldehyde (185 mg, 0.77 mmol, Example 5-29, Step 3) afforded the desired product as a yellow oil.

Quelle