Reaktion #48949

ord-f0f9042eaab34af7a44e0f7e057a5f6c

Reaktionsgleichung

O=C(O)CBr
2-bromoacetic acid
COc1ccc2c(Nc3c(Cl)cncc3Cl)cc(=O)oc2c1O
4-(3,5-dichloropyridin-4-ylamino)-8-hydroxy-7-methoxy-2H-chromen-2-one
COc1ccc2c(Nc3c(Cl)cncc3Cl)cc(=O)oc2c1OCC(=O)O
title compound
COc1ccc2c(Nc3c(Cl)cncc3Cl)cc(=O)oc2c1OCC(=O)O
2-(4-(3,5-Dichloropyridin-4-ylamino)-7-methoxy-2-oxo-2H-chromen-8-yloxy)acetic acid

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

The title compound was prepared from 2-bromoacetic acid and 4-(3,5-dichloropyridin-4-ylamino)-8-hydroxy-7-methoxy-2H-chromen-2-one (Example 29) following the procedure outlined in Example 25. 1H NMR (400 MHz, DMSO-d6): δ 12.90 (br, 1H), 9.56 (br s, 1H), 8.83 (s, 2H), 7.97 (d, 1H), 7.23 (d, 1H), 4.66 (s, 1H), 4.65 (s, 2H), 3.94 (s, 3H); MS (ESI): 410.8.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US07745646B2uspto-grants-2010_06