Reaktion #48876

Reaktionsgleichung

dimethylamine

THF

2-chloro-4,5-difluorobenzoic acid

(1-chloro-2-methylprop-1-en-1-yl)dimethylamine

triethylamine

→

title compound

Ausbeute 96.8%

2-Chloro-4,5-difluoro-N,N-dimethylbenzamide

Ausbeute 96.8%

Lösungsmittel

DCM

DCM

hydrochloric acid

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigeseparated
2. 2
   TrocknenThe organic layer was dried (MgSO4)
3. 3
   Filtrationfiltered
4. 4
   Einengenconcentrated in vacuo

Vorschrift

A solution of 2-chloro-4,5-difluorobenzoic acid (385 mg, 2.0 mmol) in DCM (5 mL) was treated with (1-chloro-2-methylprop-1-en-1-yl)dimethylamine (293 mg, 2.2 mmol) and stirred under argon for 1 hour. The mixture was then treated with triethylamine (0.56 mL, 4.0 mmol) and a 2M solution of dimethylamine in THF (1.2 mL, 2.4 mmol), and stirred for 18 hours. The mixture was diluted with DCM (5 mL) and 2M hydrochloric acid (4 mL) and separated. The organic layer was dried (MgSO4), filtered and concentrated in vacuo to afford the title compound (425 mg). The residue was used without further purification.

Quelle