Reaktion #488714

Reaktionsgleichung

2-bromo-1,1-diethoxy-ethane

hydrogen

1-(4-hydroxy-phenyl)-cyclopropanecarboxylic acid methyl ester

sodium hydride

→

1-[4-(2,2-diethoxy-ethoxy)-phenyl]-cyclopropanecarboxylic acid

Ausbeute 40.3%

Lösungsmittel

DMF

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.ADDITIONThe reaction mixture was poured onto ice (100 g)
2. 2
   Extraktionextracted with CH2Cl2
3. 3
   TrocknenThe combined organics were dried over Na2SO4
4. 4
   SonstigeThe solvent was evaporated under vacuum

Vorschrift

To a stirred solution of 1-(4-hydroxy-phenyl)-cyclopropanecarboxylic acid methyl ester (15.0 g, 84.3 mmol) in DMF (50 mL) was added sodium hydride (6.7 g, 170 mmol, 60% in mineral oil) at 0° C. After hydrogen evolution ceased, 2-bromo-1,1-diethoxy-ethane (16.5 g, 84.3 mmol) was added dropwise to the reaction mixture. The reaction was stirred at 160° C. for 15 hours. The reaction mixture was poured onto ice (100 g) and extracted with CH2Cl2. The combined organics were dried over Na2SO4. The solvent was evaporated under vacuum to give crude 1-[4-(2,2-diethoxy-ethoxy)-phenyl]-cyclopropanecarboxylic acid (10 g), which was used directly in the next step without purification.

Quelle