Reaktion #48862

Reaktionsgleichung

Azetidine

4-fluorobenzenesulfonyl chloride

→

solid

Ausbeute 8.0%

1-[(4-Fluorophenyl)sulfonyl]azetidine

Ausbeute 8.0%

Lösungsmittel

THF

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigereaction mixture
2. 2
   EinengenThe reaction mixture was concentrated in vacuo
3. 3
   SonstigeThe organic layer was separated
4. 4
   Trocknendried (MgSO4)
5. 5
   Filtrationfiltered
6. 6
   Sonstigeevaporated

Vorschrift

Azetidine (0.25 g, 4.35 mmol) was added to a solution of sodium hexamethyldisilylazide (0.85 g, 4.6 mmol) in THF (10 mL) at 0° C. and reaction mixture stirred for 10 minutes. 4-fluorobenzenesulfonyl chloride (0.85 g, 4.35 mmol) was subsequently added and the reaction mixture was allowed to warm up to ambient temperature overnight. The reaction mixture was concentrated in vacuo and the residue taken up in ethyl acetate and water. The organic layer was separated and then dried (MgSO4), filtered and evaporated to give a waxy, yellow solid (75 mg).

Quelle