Reaktion #488339

ord-c1928f7962f34a8f9a6d3e98261b013a

Reaktionsgleichung

O=C(Cc1ccc(F)c(F)c1)c1ccccc1
Intermediate 12
O=C(Cc1ccc(F)c(F)c1)c1ccccc1
2-(3,4-difluorophenyl)-1-phenylethanone
Brc1cccc(Br)c1
1,3-dibromobenzene
O=C(Cc1ccccc1)c1cccc(Br)c1
1-(3-bromophenyl)-2-phenylethanone
Ausbeute 47.7%

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    Sonstigewas purified by column chromatography (PE:EtOAc=100:1)

Vorschrift

Followed the procedure described in Intermediate 12, starting from 1,3-dibromobenzene, where the crude product was purified by column chromatography (PE:EtOAc=100:1) to give the desired 1-(3-bromophenyl)-2-phenylethanone (520 mg, yield 47.7%).

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US08741915B2uspto-grants-2014_06