Reaktion #487667

Reaktionsgleichung

hydrazine acetate

2,4-Dioxo-4-phenyl-butyric acid methyl ester

water

→

desired product

Ausbeute 66.3%

5-phenyl-1H-pyrazole-3-carboxylic acid methyl ester

Ausbeute 66.3%

Lösungsmittel

acetic acid

Reaktionsbedingungen

Aufarbeitung

1. 1
   FiltrationThe precipitate was filtered
2. 2
   workup.STIRRINGstirred with diisopropylether
3. 3
   Filtrationagain filtered

Vorschrift

983 mg hydrazine acetate was added to 2 g 2,4-Dioxo-4-phenyl-butyric acid methyl ester in 10 mL concentrated acetic acid. The mixture was stirred over night at RT. Then water was added. The precipitate was filtered, stirred with diisopropylether and again filtered to give 1.3 g desired product. Rt: 1.39 min (method O), (M+H)+: 203

Quelle