Reaktion #48749

ord-c56912b0849943d6a64374458acfdae2

Reaktionsgleichung

CC(C)(C)OC(=O)N1C[C@H](O)OCC1C(OCc1ccccc1)C(Cc1cc(F)cc(F)c1)N(Cc1ccccc1)Cc1ccccc1
(R)-5-[1-benzyloxy-2-dibenzylamino-3-(3,5-difluorophenyl)-propyl]-2-hydroxymorpholine-4-carboxylic acid tert-butyl ester
O=S(=O)(OCC1(CF)CCCC1)C(F)(F)F
trifluoromethane-sulfonic acid 1-fluoromethyl-cyclopentylmethyl ester
→
CC(C)(C)OC(=O)N1C[C@H](OCC2(CF)CCCC2)OC[C@@H]1[C@@H](OCc1ccccc1)[C@H](Cc1cc(F)cc(F)c1)N(Cc1ccccc1)Cc1ccccc1
desired compound
CC(C)(C)OC(=O)N1C[C@H](OCC2(CF)CCCC2)OC[C@@H]1[C@@H](OCc1ccccc1)[C@H](Cc1cc(F)cc(F)c1)N(Cc1ccccc1)Cc1ccccc1
(2R,5R)-5-[(1S,2S)-1-Benzyloxy-2-dibenzylamino-3-(3,5-difluoro-phenyl)-propyl]-2-(1-fluoromethyl-cyclopentylmethoxy)-morpholine-4-carboxylic acid tert-butyl ester

Edukte

CC(C)(C)OC(=O)N1C[C@H](O)OCC1C(OCc1ccccc1)C(Cc1cc(F)cc(F)c1)N(Cc1ccccc1)Cc1ccccc1
(R)-5-[1-benzyloxy-2-dibenzylamino-3-(3,5-difluorophenyl)-propyl]-2-hydroxymorpholine-4-carboxylic acid tert-butyl ester
O=S(=O)(OCC1(CF)CCCC1)C(F)(F)F
trifluoromethane-sulfonic acid 1-fluoromethyl-cyclopentylmethyl ester

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

Beginning with (R)-5-[1-benzyloxy-2-dibenzylamino-3-(3,5-difluorophenyl)-propyl]-2-hydroxymorpholine-4-carboxylic acid tert-butyl ester and trifluoromethane-sulfonic acid 1-fluoromethyl-cyclopentylmethyl ester, the desired compound may be prepared essentially as described in Preparation 306.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US07745438B2uspto-grants-2010_06