Reaktion #487290

ord-8814226c9594406cb3d3ea20a042b38a

Reaktionsgleichung

CCN1CCCC(=O)CC1
1-ethylhexahydro-4-azepinone
CCOC=O
ethyl formate
N#CCC(N)=O
cyanoacetamide
[H-].[Na+]
sodium hydride
→
CCN1CCc2cc(C#N)c(O)nc2CC1
3-Cyano-2-hydroxy-7-ethyl-6,7,8,9-tetrahydro-5H-pyrido[2,3-d]azepine

Edukte

CCN1CCCC(=O)CC1
1-ethylhexahydro-4-azepinone
CCOC=O
ethyl formate
N#CCC(N)=O
cyanoacetamide
[H-].[Na+]
sodium hydride

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

Prepared from 1-ethylhexahydro-4-azepinone by reaction with ethyl formate and cyanoacetamide in the presence of sodium hydride.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US05827849uspto-grants-1998_10