Reaktion #4872

Reaktionsgleichung

ethyl (Z)-2-(2-tritylaminothiazol-4-yl)-2-[(2-pyrrolidon-3-yl)oxyimino]acetate

sodium hydroxide

→

(Z)-2-(2-tritylaminothiazol-4-yl)-2-[(2-pyrrolidon-3-yl)oxyimino]acetic acid

Ausbeute 75.1%

Lösungsmittel

methanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturthe mixture is refluxed for 30 minutes
2. 2
   Temperaturunder heating
3. 3
   TemperaturAfter cooling
4. 4
   Sonstigecrystalline precipitates
5. 5
   Filtrationare collected by filtration
6. 6
   Waschenwashed with methanol
7. 7
   SonstigeCrystalline precipitates
8. 8
   Filtrationare collected by filtration
9. 9
   Sonstigedried

Vorschrift

16.0 g of ethyl (Z)-2-(2-tritylaminothiazol-4-yl)-2-[(2-pyrrolidon-3-yl)oxyimino]acetate are added to a mixture of 160 ml of methanol and 30 ml of an aqueous 2N sodium hydroxide solution, and the mixture is refluxed for 30 minutes under heating. After cooling, crystalline precipitates are collected by filtration and washed with methanol. The crystals are suspended in 30 ml of water. Then, the suspension is adjusted to pH 3 with 2N hydrochloric acid. Crystalline precipitates are collected by filtration and dried. 11.4 g of (Z)-2-(2-tritylaminothiazol-4-yl)-2-[(2-pyrrolidon-3-yl)oxyimino]acetic acid are obtained.

Quelle