Reaktion #487065

ord-f17162eee9fd4fa2a1cf4cb44ea995ed

Reaktionsgleichung

O=C(O)Cc1cc2ccccc2[nH]1
2-indolylacetic acid
Cc1[nH]c2ccccc2c1CC(=O)O
(2-methyl-3-indolyl)acetic acid
O=C(O)CCCc1c[nH]c2ccccc12
indole-3-butyric acid
COc1ccc2[nH]cc(CC(=O)O)c2c1
(5-methoxyindol-3-yl)acetic acid
O=C(O)Cc1cccc2c(=O)cc(-c3ccccc3)oc12
flavone-8-acetic acid
O=C(O)CCc1c[nH]c2ccccc12
3-(3-indolyl)propionic acid
O=C(O)CCCc1ccc(N(CCCl)CCCl)cc1
chlorambucil
O=C(O)Cc1ccc2c(c1)OCO2
3,4-(methylenedioxy)phenylacetic acid
O=C(O)/C=C/c1ccc2c(c1)OCO2
3,4-(methylenedioxy)cinnamic acid
O=C(O)Cc1c[nH]c2ccccc12
3-Indolylacetic acid

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    Sonstigeprepared from

Vorschrift

2-indolylacetic acid; (N-methyl)-2- or -3-indolylacetic acid; 3-(3-indolyl)propionic acid; 3- or 2-indolylacrylic acid (also (N-methyl)); (2-methyl-3-indolyl)acetic acid, 3,4-(methylenedioxy)phenylacetic acid; 3,4-(methylenedioxy)cinnamic acid; indole-3-butyric acid; (5-methoxyindol-3-yl)acetic acid; naphthyl-1- or -2-acetic acid; flavone-8-acetic acid; 5,6-dimethylxanthone-4-acetic acid (L. L. Thomsen et al.: Cancer Chemother, Pharmacol. 31, 151ff. (1992) demonstrate that the corticoid 21-carboxylic esters prepared from this could also have an antitumorigenic effect, likewise the abovementioned chlorambucil).

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US05824670uspto-grants-1998_10