Reaktion #486643

Reaktionsgleichung

4-amino-2-chlorophenyl 1-methylimidazol-2-yl sulphide

4-chloro-6,7-dimethoxyquinazoline hydrochloride

→

4-[3-chloro-4-(1-methylimidazol-2-ylthio)anilino]-6,7-dimethoxyquinazoline dihydrochloride salt

Ausbeute 71.0%

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturwas heated
2. 2
   Temperaturto reflux for 16 hours

Vorschrift

Using an analogous procedure to that described in Example 1 except that the reaction mixture was heated to reflux for 16 hours, 4-amino-2-chlorophenyl 1-methylimidazol-2-yl sulphide was reacted with 4-chloro-6,7-dimethoxyquinazoline hydrochloride to give 4-[3-chloro-4-(1-methylimidazol-2-ylthio)anilino]-6,7-dimethoxyquinazoline dihydrochloride salt in 71% yield, m.p. 244°-246° C.;

Quelle