Reaktion #48664

Reaktionsgleichung

ethyl acetate

polypropylene

1,6-dioxaspiro[2,5]octane-2-carbonitrile

hydrogen fluoride-pyridine

→

desired compound

(4-Fluorotetrahydropyran-4-yl)-hydroxyacetonitrile

Lösungsmittel

dichloromethane

Reaktionsbedingungen

Aufarbeitung

1. 1
   Waschenwash with saturated aqueous sodium bicarbonate solution until washes
2. 2
   Extraktionextract with ethyl acetate
3. 3
   ExtraktionCombine this organic extract with the ethyl acetate solution of the crude
4. 4
   Sonstigereaction mixture
5. 5
   Waschenwash with saturated aqueous sodium chloride solution
6. 6
   Trocknendry (magnesium sulfate)
7. 7
   Filtrationfilter
8. 8
   Einengenconcentrate

Vorschrift

Dissolve 1,6-dioxaspiro[2,5]octane-2-carbonitrile (4.14 g, 29.8 mmol) in dry dichloromethane (10 mL) and cool to 0° C. under a nitrogen atmosphere in a polypropylene bottle. Add hydrogen fluoride-pyridine (3 mL) dropwise. Allow the mixture to slowly warm to room temperature over 3 h and then stir an additional 1.5 hours at room temperature. Pour into ethyl acetate and wash with saturated aqueous sodium bicarbonate solution until washes remain basic. Combine the aqueous washes and adjust the pH of the solution to ˜pH=8 and extract with ethyl acetate. Combine this organic extract with the ethyl acetate solution of the crude reaction mixture and wash with saturated aqueous sodium chloride solution, dry (magnesium sulfate), filter and concentrate to give the desired compound as a yellow oil which is used directly in the next reaction.

Quelle