Reaktion #48652

Reaktionsgleichung

lithium hydroxide

trans-2-(methylpropylcarbamoyl)-cyclopropane carboxylic acid ethyl ester

→

title compound

trans-2-(Methylpropylcarbamoyl)-cyclo-propane carboxylic acid

Lösungsmittel

tetrahydrofuran

Reaktionsbedingungen

Aufarbeitung

1. 1
   EinengenConcentrate
2. 2
   workup.ADDITIONtreat with water (50 mL)
3. 3
   Extraktionextract with diethyl ether (50 mL)
4. 4
   Extraktionextract with diethyl ether (3×125 mL)
5. 5
   TrocknenCombine the organic extracts, dry (magnesium sulfate)
6. 6
   Einengenconcentrate

Vorschrift

Add 1 N lithium hydroxide (25.6 mL, 25.59 mmol) to a solution of trans-2-(methylpropylcarbamoyl)-cyclopropane carboxylic acid ethyl ester (1.02 g, 5.1194 mmol) in tetrahydrofuran (30 mL). Stir vigorously for 2 days at room temperature. Concentrate and treat with water (50 mL) and extract with diethyl ether (50 mL). Acidify the aqueous layer with 1 N hydrochloric acid (26 mL) and extract with diethyl ether (3×125 mL). Combine the organic extracts, dry (magnesium sulfate) and concentrate to give the title compound as a racemic mixture (0.84 g, 89%).

Quelle