Reaktion #4863

Reaktionsgleichung

title compound

2-[3-(2,6-dimethylphenyl)-2-propenyl]-1H-isoindole-1,3(2H)-dione

MeOH

→

2-[3-(2,6-dimethylphenyl)propyl]-1H-isoindole-1,3(2H)-dione

Lösungsmittel

THF

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe residue after removing all solvent under reduced pressure
2. 2
   Sonstigeto yield the pale yellow crystalline product which
3. 3
   Sonstigewas recrystallized from Skelly B

Vorschrift

The title compound of Example 32 (10 g, 34 mmole) dissolved in 120 ml of THF and 100 ml of MeOH was reduced in a standard Parr hydrogenation apparatus using 1 g of 5% Pd/C as catalyst. The reaction was run at room temperature under a pressure of 5 psi for 24 hours. The residue after removing all solvent under reduced pressure was chromotographed to yield the pale yellow crystalline product which was recrystallized from Skelly B. The melting point was 92°-93.5° C.

Quelle