Reaktion #486232

Reaktionsgleichung

1H-indazole-3-carboxylic acid

1,1'-carbonyldiimidazole

→

solid

Ausbeute 185.2%

N-[2-(1,2,3,4-tetrahydro-2-isoquinolinyl)ethyl]-1H-indazole-3-carboxamide

Ausbeute 185.2%

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe ethyl acetate extracts were evaporated to a solid
2. 2
   workup.ADDITIONAddition of cyclohexane and filtration

Vorschrift

Same procedure followed as described in Example 5. The following amounts were used: 1H-indazole-3-carboxylic acid (1.49 g, 9.2 mmol), 1,1'-carbonyldiimidazole (1.49 g, 9.2 mmol) and the intermediate from Preparation 5 (1.62 g, 9.2 mmol). The ethyl acetate extracts were evaporated to a solid. Addition of cyclohexane and filtration provided 2.73 g of solid. Mass spectrum, m+ =321.

Quelle