Reaktion #48606

Reaktionsgleichung

potassium carbonate

3,5-difluorobenzaldehyde

nitromethane

→

desired compound

1-(3,5-Difluorophenyl)-2-nitroethanol

Lösungsmittel

tetrahydrofuran

Reaktionsbedingungen

Aufarbeitung

1. 1
   Filtrationfilter
2. 2
   Waschenwash with ethyl acetate
3. 3
   Einengenconcentrate

Vorschrift

Add nitromethane (200 mL) to a suspension of potassium carbonate (30 g) and 3,5-difluorobenzaldehyde (200 g) in tetrahydrofuran (600 mL) at room temperature. Stir at room temperature overnight, filter, wash with ethyl acetate and concentrate to give the desired compound as a crude oil (330 g) which is used in the next step without further purification.

Quelle