Reaktion #486025

Reaktionsgleichung

4-amino-2,6-dichloropyridine

sodium chloride

hydrochloric acid

sodium nitrite

→

2,4,6-trichloropyridine

Lösungsmittel

water

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.ADDITIONwas added little by little
2. 2
   Extraktionthe mixture was extracted with chloroform
3. 3
   ExtraktionAfter the obtained extract
4. 4
   Trocknenwas dried over anhydrous sodium sulfate, solvent
5. 5
   workup.DISTILLATIONwas distilled off under reduced pressure

Vorschrift

To a mixture composed of 4-amino-2,6-dichloropyridine (5.5 g), cuprous chloride (4.4 g) and concentrated hydrochloric acid (50 ml), sodium nitrite (3.5 g) was added little by little under cooling with ice and sodium chloride. After the resultant mixture was stirred for one hour at the same temperature and for one and a half hour at a room temperature, water was added, and the mixture was extracted with chloroform. After the obtained extract was dried over anhydrous sodium sulfate, solvent was distilled off under reduced pressure to give 2,4,6-trichloropyridine (5.5 g).

Quelle