Reaktion #48600

Reaktionsgleichung

4-methoxybenzyl chloride

4-iodo-1H-pyrazole-3-carboxylic acid phenylamide

potassium carbonate

→

4-iodo-1-(4-methoxy-benzyl)-1H-pyrazole-3-carboxylic acid phenylamide

Ausbeute 71.2%

Lösungsmittel

acetonitrile

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigethen evaporated under reduced pressure
2. 2
   SonstigeThe residue was partitioned between ethyl acetate and brine
3. 3
   Sonstigethe ethyl acetate layer was separated
4. 4
   Trocknendried (MgSO4)
5. 5
   Filtrationfiltered
6. 6
   Sonstigeevaporated
7. 7
   SonstigeThe crude material was purified by flash column chromatography
8. 8
   Wascheneluting with 1:3 ethyl acetate/hexane
9. 9
   workup.ADDITIONthe product containing fractions
10. 10
    Sonstigeevaporated

Vorschrift

A solution of 4-iodo-1H-pyrazole-3-carboxylic acid phenylamide (670 mg; 2.14 mmol) in acetonitrile (10 ml) was treated with potassium carbonate (360 mg; 2.57 mmol)) followed by 4-methoxybenzyl chloride (320 μl; 2.35 mmol). The mixture was stirred at room temperature overnight then evaporated under reduced pressure. The residue was partitioned between ethyl acetate and brine; the ethyl acetate layer was separated, dried (MgSO4), filtered and evaporated. The crude material was purified by flash column chromatography eluting with 1:3 ethyl acetate/hexane and the product containing fractions combined and evaporated to give 660 mg of 4-iodo-1-(4-methoxy-benzyl)-1H-pyrazole-3-carboxylic acid phenylamide.

Quelle