Reaktion #48578

Reaktionsgleichung

4-nitro-1-(tetrahydro-pyran-2-yl)-1H-pyrazole-3-carboxylic acid [4-(tetrahydro-pyran-2-yloxy)-cyclohexyl]-amide

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required product

Ausbeute 165.8%

4-Amino-pyrazol-3-yl carboxylic acid 4-hydroxy-cyclohexylamide

Ausbeute 165.8%

Lösungsmittel

methanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigethen hydrogenated at room temperature
2. 2
   Sonstigepressure overnight
3. 3
   SonstigeThe catalyst was removed by filtration
4. 4
   Waschenwashed three times with methanol
5. 5
   SonstigeThe filtrate was evaporated

Vorschrift

A solution of 4-nitro-1-(tetrahydro-pyran-2-yl)-1H-pyrazole-3-carboxylic acid [4-(tetrahydro-pyran-2-yloxy)-cyclohexyl]-amide (0.3 g; 0.71 mmol) in methanol (25 ml), was treated with 10% palladium on carbon (30 mg) then hydrogenated at room temperature and pressure overnight. The catalyst was removed by filtration and washed three times with methanol. The filtrate was evaporated to give 0.264 g of the required product. (LC/MS: Rt 2.39, [M+H]+ 393).

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