Reaktion #485450

ord-10fc2f331d494ab98626452552a212b1

Reaktionsgleichung

CC(c1ccccc1)C(N)C(=O)O
β-methyl-DL-phenylalanine
O=S(=O)(Cl)c1ccc(Cl)s1
5-chlorothiophene-2-sulfonyl chloride
O=S(=O)(Cl)c1ccc(Br)s1
5-bromothiophene-2-sulfonyl chloride
CC[C@@H](C)[C@H](N)C(=O)O
L-allo-isoleucine
N[C@H](C(=O)O)C1CCCCC1
L-cyclohexylglycine
→
O=S(=O)(N[C@H](CO)C1CCCCC1)c1ccc(Cl)s1
5-Chloro-N-[(1S)-1-cyclohexyl-2-hydroxyethyl]thiophene-2-sulfonamide

Edukte

CC(c1ccccc1)C(N)C(=O)O
β-methyl-DL-phenylalanine
O=S(=O)(Cl)c1ccc(Cl)s1
5-chlorothiophene-2-sulfonyl chloride
O=S(=O)(Cl)c1ccc(Br)s1
5-bromothiophene-2-sulfonyl chloride
CC[C@@H](C)[C@H](N)C(=O)O
L-allo-isoleucine
N[C@H](C(=O)O)C1CCCCC1
L-cyclohexylglycine

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    SonstigeThe following compounds (Examples 12-17, Table 4) were prepared

Vorschrift

The following compounds (Examples 12-17, Table 4) were prepared using 5-chlorothiophene-2-sulfonyl chloride, and 5-bromothiophene-2-sulfonyl chloride with L-cyclohexylglycine, β-methyl-DL-phenylalanine, and L-allo-isoleucine and following the procedure outlined in Example 12.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US06610734B2uspto-grants-2003_08