Reaktion #485205

Reaktionsgleichung

p-hydroxy phenyl glycine

methanol

→

p-hydroxy phenyl glycine methyl ester

Ausbeute 99.0%

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturcooled in an ice bath
2. 2
   SonstigeHCl (gas) was bubbled through the reaction mixture for 20 minutes
3. 3
   Sonstigeto give a clear solution
4. 4
   Einengenconcentrated in vacuo
5. 5
   Sonstigeto give an oil which
6. 6
   Sonstigewas triturated with ethyl ether

Vorschrift

The p-hydroxy phenyl glycine (74.0 g, 442 mmol) was suspended in methanol (500 mL), cooled in an ice bath and HCl (gas) was bubbled through the reaction mixture for 20 minutes, to give a clear solution. The reaction was stirred at rt for 48 h, concentrated in vacuo to give an oil which was triturated with ethyl ether to give the p-hydroxy phenyl glycine methyl ester (95.8 g, 99%) as a white powder. MS found: (M+H)+=182.

Quelle