Reaktion #484920

Reaktionsgleichung

N-Ethyl-1,2,3,6-tetrahydro-4-(3-(1-methylethoxy)phenyl)pyridine

→

title compound

Ausbeute 99.1%

N-Ethyl-4-(3-(1-methylethoxy)phenyl)piperidine

Ausbeute 99.1%

Lösungsmittel

ethanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   TemperaturThe mixture was cooled
2. 2
   Sonstigethe solid was removed by filtration through Arbocel™
3. 3
   Waschenwashing the resultant cake with ethyl acetate
4. 4
   EinengenThe filtrate was concentrated in vacuo

Vorschrift

N-Ethyl-1,2,3,6-tetrahydro-4-(3-(1-methylethoxy)phenyl)pyridine (Preparation 44, 2.0 g, 8.16 mmol) was dissolved in ethanol (20 ml) and 5% palladium on carbon (0.2 g) was added. The suspension was heated at 60° C. under hydrogen (20 psi) for 5 h. The mixture was cooled and the solid was removed by filtration through Arbocel™, washing the resultant cake with ethyl acetate. The filtrate was concentrated in vacuo to give the title compound as an oil (2.0 g, 99%) which was used without further purification.

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