Reaktion #484873

ord-e7677b96e87e47b1a7b81a6c1509a510

Reaktionsgleichung

O=C(O)[C@@H]1CCCCN1S(=O)(=O)c1ccc(F)cc1
(2S)-1-[(4-fluorophenyl)sulfonyl]-2-piperidinecarboxylic acid
CC(N)=NO
N′1-hydroxyethanimidamide
CN1CCOCC1
N-methyl morpholine
O.Oc1cccc2[nH]nnc12
hydroxybenzotriazole hydrate
CCN=C=NCCCN(C)C.Cl
1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride
→
CC(N)=NOC(=O)[C@@H]1CCCCN1S(=O)(=O)c1ccc(F)cc1
N′1-[((2S)-1-[(4-fluorophenyl)sulfonyl]-2-piperidylcarbonyl)oxy]ethanimidamide

Edukte

O=C(O)[C@@H]1CCCCN1S(=O)(=O)c1ccc(F)cc1
(2S)-1-[(4-fluorophenyl)sulfonyl]-2-piperidinecarboxylic acid
CC(N)=NO
N′1-hydroxyethanimidamide
CN1CCOCC1
N-methyl morpholine
O.Oc1cccc2[nH]nnc12
hydroxybenzotriazole hydrate
CCN=C=NCCCN(C)C.Cl
1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

The title compound was prepared by a similar method to Preparation 39 from (2S)-1-[(4-fluorophenyl)sulfonyl]-2-piperidinecarboxylic acid [see Preparation 38], N′1-hydroxyethanimidamide [La Manna, et al, Theochem (1990), 69, 161-68], N-methyl morpholine, hydroxybenzotriazole hydrate and 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride, to afford N′1-[((2S)-1-[(4-fluorophenyl)sulfonyl]-2-piperidylcarbonyl)oxy]ethanimidamide as a colourless gum.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US06610707B1uspto-grants-2003_08