Reaktion #484829

Reaktionsgleichung

Sodium sulfite heptahydrate

3-(bromomethyl)tetrahydrofuran

→

sodium tetrahydrofuran-3-ylmethanesulfonate

Ausbeute 57.0%

Lösungsmittel

1,4-dioxane

water

Reaktionsbedingungen

Aufarbeitung

1. 1
   TemperaturThe reaction mixture was then heated
2. 2
   Temperaturunder reflux
3. 3
   Temperaturcooled
4. 4
   Sonstigethe solvent removed under reduced pressure
5. 5
   workup.DISSOLUTIONThe resulting solid was dissolved in water
6. 6
   Einengenconcentrated to a low volume
7. 7
   SonstigeThe solid formed
8. 8
   Sonstigewas then collected

Vorschrift

Sodium sulfite heptahydrate (6.10 g) was added to a solution of 3-(bromomethyl)tetrahydrofuran (2.0 g) [see Preparation 9] in 1,4-dioxane (9 ml) and water (9 ml). The reaction mixture was then heated under reflux and stirred for 18 hours, cooled and the solvent removed under reduced pressure. The resulting solid was dissolved in water and concentrated to a low volume. The solid formed was then collected to afford sodium tetrahydrofuran-3-ylmethanesulfonate (1.30 g) as a white solid.

Quelle