Reaktion #484489

Reaktionsgleichung

oxalyl chloride

(4(S)-phenyloxazolidin-2-on-3-yl)acetic acid

dimethylformamide

→

(4(S)-Phenyloxazolidin-2-on-3-yl)acetyl Chloride

Lösungsmittel

dichloromethane

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigeresulted in vigorous gas evolution
2. 2
   Einengenthe reaction mixture was concentrated under reduced pressure
3. 3
   SonstigeThe title compound, recovered as an off-white solid
4. 4
   Sonstigewas dried at 0.5 mm Hg for 10 minutes before use in subsequent reactions

Vorschrift

To a solution of 1.31 gm (5.93 mMol) (4(S)-phenyloxazolidin-2-on-3-yl)acetic acid (Evans, U.S. Pat. No. 4,665,171) in 200 mL dichloromethane was added 0.67 mL (7.71 mMol) oxalyl chloride. To this solution was then added 0.5 mL anhydrous dimethylformamide which resulted in vigorous gas evolution. After 45 minutes all gas evolution had ceased and the reaction mixture was concentrated under reduced pressure. The title compound, recovered as an off-white solid, was dried at 0.5 mm Hg for 10 minutes before use in subsequent reactions.

Quelle