Reaktion #484293

Reaktionsgleichung

sodium methoxide

ethyl 1-[(2′-cyanobiphenyl-4-yl)methyl]-2-methoxybenzimidazole-7-carboxylate

→

Methyl 1-[(2′-cyanobiphenyl-4-yl)methyl]-2-methoxybenzimidazole-7-carboxylate

Lösungsmittel

methanol

methanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   TemperaturThe mixture was heated for 4 hours
2. 2
   Temperaturunder reflux
3. 3
   EinengenThe reaction mixture was concentrated
4. 4
   Filtrationthe precipitated crystals were collected by filtration
5. 5
   SonstigeRecrystallization from methanol afforded colorless prisms (1.1 g, 85%), m.p. 149-150° C.

Vorschrift

A solution of 5.2M sodium methoxide in methanol (0.5 ml) was added to a solution of ethyl 1-[(2′-cyanobiphenyl-4-yl)methyl]-2-methoxybenzimidazole-7-carboxylate (1.3 g) in methanol (50 ml). The mixture was heated for 4 hours under reflux. The reaction mixture was concentrated, and the precipitated crystals were collected by filtration. Recrystallization from methanol afforded colorless prisms (1.1 g, 85%), m.p. 149-150° C.

Quelle