Reaktion #48410

Reaktionsgleichung

Trifluoroacetic acid

tert-butyl (3R,6S)-6-(2,3-difluorophenyl)-2-oxoazepan-3-ylcarbamate

→

(3R,6S)-3-Amino-6-(2,3-difluorophenyl)azepan-2-one

Lösungsmittel

dichloromethane

Reaktionsbedingungen

Aufarbeitung

1. 1
   Einengenthe solution was concentrated
2. 2
   workup.ADDITIONSaturated aqueous sodium bicarbonate solution was added
3. 3
   Extraktionthe mixture was extracted with dichloromethane (3×)
4. 4
   WaschenThe combined organic extracts were washed with saturated brine
5. 5
   Trocknendried over magnesium sulfate
6. 6
   Filtrationfiltered
7. 7
   Einengenconcentrated

Vorschrift

Trifluoroacetic acid (4 mL) was added to a solution of tert-butyl (3R,6S)-6-(2,3-difluorophenyl)-2-oxoazepan-3-ylcarbamate (82 mg, 0.241 mmol) in dichloromethane (4 mL). After 1 h, the solution was concentrated. Saturated aqueous sodium bicarbonate solution was added and the mixture was extracted with dichloromethane (3×). The combined organic extracts were washed with saturated brine, dried over magnesium sulfate, filtered and concentrated. MS 241.0 (M+1)

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