Reaktion #483932

ord-d67e9e19ed5142bfbdd11ffdf188bf22

Reaktionsgleichung

Cc1cc(-c2ccc(S(C)(=O)=O)cc2)n(-c2ccc(Br)cc2)c1C
1-(4-bromophenyl)-2,3-dimethyl-5-[4-(methylsulfonyl)phenyl]-1H-pyrrole
OB(O)c1ccoc1
3-furanboronic acid
→
Cc1cc(-c2ccc(S(C)(=O)=O)cc2)n(-c2ccc(-c3ccoc3)cc2)c1C
title compound
Cc1cc(-c2ccc(S(C)(=O)=O)cc2)n(-c2ccc(-c3ccoc3)cc2)c1C
2,3-Dimethyl-1-[4-(3-furyl)phenyl]-5-[4-(methylsulfonyl)phenyl]-1H-pyrrole

Edukte

Cc1cc(-c2ccc(S(C)(=O)=O)cc2)n(-c2ccc(Br)cc2)c1C
1-(4-bromophenyl)-2,3-dimethyl-5-[4-(methylsulfonyl)phenyl]-1H-pyrrole
OB(O)c1ccoc1
3-furanboronic acid

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

The title compound was prepared according to the procedure of Example 35 using 1-(4-bromophenyl)-2,3-dimethyl-5-[4-(methylsulfonyl)phenyl]-1H-pyrrole instead of 1-(4-bromophenyl)-2-[3-fluoro-4-(methylsulfonyl)phenyl]-5-methyl-1H-pyrrole and 3-furanboronic acid instead of 2-furanboronic acid in step 4.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US06608095B2uspto-grants-2003_08