Reaktion #48356

Reaktionsgleichung

methyl 3-[(1-benzylpiperidin-4-yl)amino]pyrazine-2-carboxylate

hydrazine hydrate

→

title compound

3-[(1-Benzylpiperidin-4-yl)amino]pyrazine-2-carbohydrazide

Lösungsmittel

ethanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturwas refluxed
2. 2
   TemperaturThe reaction was cooled
3. 3
   Einengenconcentrated

Vorschrift

A mixture of methyl 3-[(1-benzylpiperidin-4-yl)amino]pyrazine-2-carboxylate (3.0 g, 9.2 mmol) and hydrazine hydrate (6 mL) in ethanol (100 mL) was refluxed with stirring for 2 h. The reaction was cooled and concentrated to give the title compound (3.0 g). MS 327 (M+1).

Quelle