Reaktion #48308

ord-64d1d7ba6333472782ac0a3b90a1e555

Reaktionsgleichung

COC(=O)[C@@H](CI)C(=O)OC(C)(C)C
(R)-methyl 2-(tert-butoxycarbonyl)-3-iodopropanoate
Clc1csc(Cl)n1
2,4-dichlorothiazole
→
COC(=O)[C@H](Cc1nc(Cl)cs1)C(=O)OC(C)(C)C
title compound
COC(=O)[C@H](Cc1nc(Cl)cs1)C(=O)OC(C)(C)C
(S)-methyl 2-(tert-butoxycarbonyl)-3-(4-chlorothiazol-2-yl)propanoate

Edukte

COC(=O)[C@@H](CI)C(=O)OC(C)(C)C
(R)-methyl 2-(tert-butoxycarbonyl)-3-iodopropanoate
Clc1csc(Cl)n1
2,4-dichlorothiazole

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    Sonstigeprepared
  2. 2
    SonstigeNew synthesis of the thiazole ring

Vorschrift

The title compound was synthesized in a manner analogous to that described Example 475, using (R)-methyl 2-(tert-butoxycarbonyl)-3-iodopropanoate and 2,4-dichlorothiazole (prepared according to Reynaud, Pierre; Robba, Max; Moreau, Robert C; New synthesis of the thiazole ring; Bulletin de la Societe Chimique de France (1962), 1735-8). MS m/z: 321 (23%, M+1), 265.0 (100%, M−55.1).

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US07745484B2uspto-grants-2010_06