Reaktion #482800

Reaktionsgleichung

2-chloro-4-(4-chlorophenyl)-5-[3-(2-methylphenoxy)propyl]oxazole

2-ethylimidazole

potassium carbonate

N,N-dimethylformamide

→

4-(4-chlorophenyl)-2-(2-ethyl-1-imidazolyl)-5-[3-(2-methylphenoxy)propyl]oxazole

Ausbeute 38.0%

Lösungsmittel

water

Reaktionsbedingungen

Aufarbeitung

1. 1
   Filtrationthe solid precipitate was filtered
2. 2
   Sonstigeair-dried
3. 3
   Sonstigerecrystallized from acetone-isopropyl ether

Vorschrift

A mixture of 2-chloro-4-(4-chlorophenyl)-5-[3-(2-methylphenoxy)propyl]oxazole (1.00 g), 2-ethylimidazole (960 mg), potassium carbonate (1.38 g) and N,N-dimethylformamide (10 ml) was stirred at 120-130° C. for 1 hour. The reaction mixture was poured into water (100 ml), and the solid precipitate was filtered, air-dried and recrystallized from acetone-isopropyl ether to give 4-(4-chlorophenyl)-2-(2-ethyl-1-imidazolyl)-5-[3-(2-methylphenoxy)propyl]oxazole as pale yellow prisms (438 mg, 38%). Melting point 91-92° C.

Quelle