Reaktion #48271

Reaktionsgleichung

Psi

4-Benzyloxy-3-methoxy-N-(3-benzyloxy-4-methoxyphenyl)benzamide

→

3-hydroxy-N-(3-hydroxy-4-methoxyphenyl)-4-methoxybenzamide

Ausbeute 41.6%

Lösungsmittel

N,N-dimethylformamide methanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeRemoval of the catalyst
2. 2
   Filtrationby filtration and purification by flash chromatography over silica gel eluting with 65% ethyl acetate/hexane

Vorschrift

A solution of the 4-Benzyloxy-3-methoxy-N-(3-benzyloxy-4-methoxyphenyl)benzamide (1.05 g) in a mixture of N,N-dimethylformamide/methanol (1:5, 120 ml) was hydrogenated in presence of 10% palladium on carbon at 40 Psi at room temperature for 12 hrs. Removal of the catalyst by filtration and purification by flash chromatography over silica gel eluting with 65% ethyl acetate/hexane provided 0.26 g of 3-hydroxy-N-(3-hydroxy-4-methoxyphenyl)-4-methoxybenzamide. Yield=41.6%

Quelle