Reaktion #48270

Reaktionsgleichung

1-benzyloxy-2-methoxy-5-aminobenzene

4-benzyloxy-3-methoxy benzoic acid

1-hydroxybenzotriazole

→

4-Benzyloxy-3-methoxy-N-(3-benzyloxy-4-methoxyphenyl)benzamide

Ausbeute 71.0%

Lösungsmittel

N,N-dimethylformamide

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe product was precipitated
2. 2
   workup.ADDITIONby diluting with a mixture of ethyl acetate/hexane (1:1) (120 ml)
3. 3
   FiltrationFiltration of the reaction mixture

Vorschrift

N,N-1,3-Diisopropyl carbodiimide (0.40 g, 3.36 mmol) was added to a solution of 1-benzyloxy-2-methoxy-5-aminobenzene (0.771 g, 3.36 mmol), 4-benzyloxy-3-methoxy benzoic acid (0.87 g, 3.36 mmol) and 1-hydroxybenzotriazole (0.454 g, 3.36 mmol) in N,N-dimethylformamide (15 ml) and stirred for 12 hrs. The product was precipitated by diluting with a mixture of ethyl acetate/hexane (1:1) (120 ml). Filtration of the reaction mixture provided 1.12 g of 4-Benzyloxy-3-methoxy-N-(3-benzyloxy-4-methoxyphenyl)benzamide. Yield 69%.

Quelle