Reaktion #482556

Reaktionsgleichung

1,1-bismethylthio-2-nitroethylene

3-aminoacetophenone

→

yellow powder

Ausbeute 65.0%

N-[1-(Methylthio)-2-nitroethenyl]-3-acetylbenzenamine

Ausbeute 65.0%

Reaktionsbedingungen

Aufarbeitung

1. 1
   TemperaturThe mixture was cooled to room temperature
2. 2
   Wascheneluting with 50% ethyl acetate/hexanes

Vorschrift

A neat mixture of 1,1-bismethylthio-2-nitroethylene (6.5 g, 38.5 mmol, 10 eq) and 3-aminoacetophenone (0.5 g, 3.85 mmol, 1 eq) was melted together and heated at 140° C. for four hours. The mixture was cooled to room temperature, then subjected to flash chromatography, eluting with 50% ethyl acetate/hexanes, to yield 0.63 g of a yellow powder as product. Yield=65%. NMR (300 MHz, CDCl3) δ 11.82 (bs, 1H), 7.95-7.91 (m, 2H), 7.59-7.48 (m, 2H), 6.73 (s, 1H), 2.65 (s, 3H), 2.41 (s, 3H).

Quelle