Reaktion #482535

Reaktionsgleichung

2,6-Dinitrobenzenecarbonitrile

ethylpiperazine

H2O

→

desired product

2-(4-Ethylpiperazinyl)-6-nitrobenzenecarbonitrile

Lösungsmittel

DMF

Reaktionsbedingungen

Aufarbeitung

1. 1
   TemperaturThe solution was cooled to room temperature
2. 2
   SonstigeA precipitate formed which
3. 3
   Filtrationwas filtered

Vorschrift

2,6-Dinitrobenzenecarbonitrile (1.0 eq) and ethylpiperazine (3.6 eq) were dissolved in DMF. The resulting solution heated at 90° C. for 2 hours. The solution was cooled to room temperature and poured into H2O. A precipitate formed which was filtered to yield the desired product as a brown solid. LC/MS m/z260.1 (MH+), Rf 1.69 minutes. 6-Amino-2-(4-ethylpiperazinyl)benzenecarbonitrile

Quelle