Reaktion #481706

Reaktionsgleichung

7-Chloro-furo[3,2-c]pyridine-2-carboxylic acid

thionyl chloride

sodium carbonate

→

title compound

7-Chloro-furo[3,2-c]pyridine-2-carboxylic acid chloride

Lösungsmittel

dichloromethane

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturheated
2. 2
   Temperaturto reflux for 16 h under nitrogen atmosphere
3. 3
   Filtrationfiltered
4. 4
   SonstigeThe filtrate was evaporated

Vorschrift

7-Chloro-furo[3,2-c]pyridine-2-carboxylic acid (prepared according to the method of Example 132, Step A, 8.94 g, 45.2 mmol) was combined with thionyl chloride (30 mL) and sodium carbonate (9.59 g, 90.5 mmol) and heated to reflux for 16 h under nitrogen atmosphere. The cooled mixture was diluted with dichloromethane and filtered. The filtrate was evaporated to give the title compound of Example 132, Step B as an orange oil, 9.19 g (94%). The acid chloride was used directly without further purification.

Quelle