Reaktion #481576

Reaktionsgleichung

methyl heptanoate

lithium diisopropylamide

4-benzyloxy-2-methyl-benzaldehyde

→

2-[(4-benzyloxy-2-methyl-phenyl)-hydroxy-methyl]-heptanoic acid methyl ester

Lösungsmittel

tetrahydrofuran

Reaktionsbedingungen

Vorschrift

In analogy to the procedure described in example 125 a], methyl heptanoate was deprotonated with lithium diisopropylamide and reacted with 4-benzyloxy-2-methyl-benzaldehyde in tetrahydrofuran to obtain 2-[(4-benzyloxy-2-methyl-phenyl)-hydroxy-methyl]-heptanoic acid methyl ester as a mixture of two diastereomeric racemates as light yellow oil.

Quelle